Caspase‐cleaved cytokeratin 18 and 20 S proteasome in liver degeneration

serum cytokeratin-18 levels for liver fibrosis prediction

Serum Cytokeratin-18 Levels for Liver Fibrosis Prediction

We have read with great interest the meta-analysis by Yang et al. (1). The reported objective was to evaluate the relation between cytokeratin-18 (CK-18) levels and hepatitis pathogenesis. Eight case-control studies were included in the meta-analysis according to the selection criteria adopted. High serum CK-18 levels were found in patients with hepatitis compared to controls. Moreover, increas...

Adipocytokines and cytokeratin-18 in patients with nonalcoholic fatty liver disease: Introduction of CHA index.

BACKGROUND AND RATIONALE Insulin resistance (IR), adipocytokines, oxidative stress and hepatic apoptosis play a pathogenetic role in nonalcoholic fatty liver disease (NAFLD). AIMS The evaluation of specific adipocytokines and markers of IR, oxidative stress and apoptosis in NAFLD patients; the introduction of a combined non-invasive index for nonalcoholic steatohepatitis (NASH). MATERIAL AN...

Biological functions of cytokeratin 18 in cancer.

The structural proteins cytokeratin 18 (CK18) and its coexpressed complementary partner CK8 are expressed in a variety of adult epithelial organs and may play a role in carcinogenesis. In this study, we focused on the biological functions of CK18, which is thought to modulate intracellular signaling and operates in conjunction with various related proteins. CK18 may affect carcinogenesis throug...

Cytokeratin 20-positive hepatocellular carcinoma

The differential diagnosis between hepatocellular carcinoma (HCC), cholangiocarcinoma (CC) and metastatic colorectal adenocarcinoma (MCA) may be difficult when only based on morphology. For this purpose immunohistochemical analyses are often required, utilizing antibodies directed against CK8-18, Hep-Par1, glypican 3, CK7, CK19, CK20. Here we report a case of a 65-year-old man who presented wit...